Ketamine hydrochloride CKTM is a dissociative anesthetic agent, with a unique position in the anesthetic practice. It was first described in the literature in and approved by the Food and Drug Administration FDA in , being introduced commercially with the manufacturers description as that of a "general anesthesia non-barbiturate of rapid action. In addition, inadequate responses that for a time carried out its minimum use, could be minimized or avoided with the use of adjuvant drugs such as benzodiazepines and butyrophenones. This drug has contributed significantly to the anesthetic-analgesic knowledge, as well as depressive and schizophrenic symptoms. Today, it continues to shed light on the molecular basis of pain, hypnosis and the physiopathology of different neuropsychiatric disorders.
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