The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging to Candida albicans, although other systemic co-factors, such as vitamin deficiency and generalized immune suppression, may play a contributory role. Clinically, the lesions are symptomless and regress after appropriate antifungal therapy and correction of underlying nutritional or other deficiencies. If the lesions are untreated, a minor proportion may demonstrate dysplasia and develop into carcinomas. This review outlines the demographic features, etiopathogenesis, immunological features, histopathology, and the role of Candida in the disease process.
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Martin MV. J Med Vet Mycol , 27 2 , 01 Jan Cited by 9 articles PMID: Dupont B , Drouhet E. J Med Vet Mycol , 26 1 , 01 Feb Cited by 45 articles PMID: J Infect Dis , 4 , 01 Apr Cited by 24 articles PMID: J Oral Maxillofac Surg , 49 9 , 01 Sep Cited by 13 articles PMID: Coronavirus: Find the latest articles and preprints.
Smart citations by scite. The number of the statements may be higher than the number of citations provided by EuropePMC if one paper cites another multiple times or lower if scite has not yet processed some of the citing articles. Explore citation contexts and check if this article has been supported or contradicted. Oral medicine: Chronic hyperplastic candidosis. Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. Management of potentially malignant disorders: evidence and critique.
Strain persistence of invasive Candida albicans in chronic hyperplastic candidosis that underwent malignant change. A comparison of fluconazole and ketoconazole in the treatment of rat palatal candidosis.
Fluconazole in the management of oropharyngeal candidosis in a predominantly HIV antibody-positive group of patients. Single-dose therapy for oral candidiasis with fluconazole in HIV-infected adults: a pilot study. Diagnosis and treatment of oral candidosis. This website requires cookies, and the limited processing of your personal data in order to function.
Treatment of candidal leukoplakia with fluconazole.
Surgical management of chronic hyperplastic candidiasis refractory to systemic antifungal treatment
Chronic Hyperplastic Candidosis/Candidiasis (Candidal Leukoplakia)
Chronic hyperplastic candidiasis CHC , earlier known as candidal leukoplakia, is a variant of oral candidiasis that classically presents as a white patch on the commissures of the oral mucosa and it is mostly caused by Candida albicans. Clinically, the lesions are usually asymptomatic and regress after appropriate antifungal therapy and correction of the underlying cause. If the lesions are untreated, a small portion may develop dysplasia and later progress into carcinoma. The purpose of this article is to report a case of CHC in a year-old male patient with a significant smoking habit, who presented with a thick, nonscrapable, brownish-white coating on the dorsum of the tongue for 9 years. This case is of particular importance and concern because of the high risk for malignant transformation in CHC.