GLIOSIS REACTIVA PDF

Background: Reactive gliosis and scar formation after brain injury can inhibit the recovery process. As many glial cells utilize gap junctions for intercellular signaling, this study investigated whether two commonly used gap junction blockers, octanol and carbenoxolone, could attenuate reactive gliosis following a minor traumatic brain injury. Immunohistochemistry for BrdU and markers for reactive glial cells [glial fibrillary acidic protein GFAP , ED1, and NG2] were investigated using immunohistochemistry and western blot techniques. Results: Two days after injury, increased cellular proliferation, activated astrocytes and microglia, and upregulation of NG2 expression were observed surrounding the injury site. Conclusion: The present study demonstrates that two important components of reactive gliosis, cellular activation and proliferation, can be attenuated by octanol and carbenoxolone. This site needs JavaScript to work properly.

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Click here to learn What's New at our website. Page views in 8, Cite this page: Abdelzaher E. Glioma - general. Accessed June 4th, Benign: does not recur; applies to pilocytic astrocytomas, certain gangliogliomas and ependymomas; may still have poor prognosis due to location that makes it difficult to resect completely Low grade: may recur as high grade and kill patient Gliomatosis cerebri: diffuse and extensive involvement of CNS associated rarely with glioma; MRI and biopsy helpful for diagnosis.

Microscopic histologic description. Biopsies of tumor epicenter have cellularity greater than surrounding brain Biopsies of margin only are difficult to grade; often contain granular calcifications among hypercellular glia Also microcysts and mitotic figures depending on tumor grade May have uneven distribution of cellular density that obscures gray white junction or spawns secondary structures of Scherer subpial and perineuronal neoplastic glia.

Collagen , reticulin , fibronectin. Differential diagnosis. Gliosis: even distribution of cellular density, contracts instead of expanding near hypercellular glia; usually less pleomorphism, no nuclear hyperchromasia, no nuclear cluster formation, no nuclear molding, no mitotic figures, no calcifications. Home About Us Advertise Amazon. Telephone: ; Email: CommentsPathout gmail.

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Trauma-induced Reactive Gliosis Is Reduced After Treatment With Octanol and Carbenoxolone

Gliosis is a nonspecific reactive change of glial cells in response to damage to the central nervous system CNS. In most cases, gliosis involves the proliferation or hypertrophy of several different types of glial cells, including astrocytes , microglia , and oligodendrocytes. In its most extreme form, the proliferation associated with gliosis leads to the formation of a glial scar. The process of gliosis involves a series of cellular and molecular events that occur over several days. This process, which constitutes a form of gliosis known as microgliosis, begins within hours of the initial CNS injury. Gliosis has historically been given a negative connotation due to its appearance in many CNS diseases and the inhibition of axonal regeneration caused by glial scar formation.

FERDINAND DE SAUSSURE CURS DE LINGVISTICA GENERALA PDF

Click here to learn What's New at our website. Page views in 8, Cite this page: Abdelzaher E. Glioma - general. Accessed June 4th, Benign: does not recur; applies to pilocytic astrocytomas, certain gangliogliomas and ependymomas; may still have poor prognosis due to location that makes it difficult to resect completely Low grade: may recur as high grade and kill patient Gliomatosis cerebri: diffuse and extensive involvement of CNS associated rarely with glioma; MRI and biopsy helpful for diagnosis. Microscopic histologic description.

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