Jaundice in Plasmodium falciparum malaria is multifactorial and its incidence varies in different regions. It is important to assess the incidence and factors associated with malarial hepatopathy as well as its complications to understand the pattern of disease presentation in order to undertake appropriate interventional measures. There is a paucity of data with regard to malarial hepatopathy and its outcome at the global level. The study was conducted to assess the pattern, spectrum of biochemical parameters and complications of hepatopathy related to P. A descriptive study was conducted in a tertiary care hospital attached to a government medical institution in Assam, India.
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Jaundice is a common clinical presentation in severe malaria, seen in approximately 2. Although hepatic dysfunction is unusual and hepatic encephalopathy is almost never seen in malaria, yet, cases of hepatic dysfunction are being increasingly reported in patients with P. The extent of hepatocellular dysfunction varies from mild abnormalities in liver function tests to hepatic failure. Patients with hepatocellular dysfunction in malaria are more prone to develop complications, but have a favorable outcome if hepatic involvement is recognized early and managed properly.
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Send at most: 1 item 5 items 10 items 20 items 50 items items items. Send even when there aren't any new results. Optional text in email:. Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Abstract Jaundice is a common clinical presentation in severe malaria, seen in approximately 2. Similar articles Jaundice in malaria. Anand AC, Puri P. Anand AC, et al. J Gastroenterol Hepatol.
PMID: Review. Hepatitis in falciparum malaria. Murthy GL, et al. Trop Gastroenterol. PMID: Malarial hepatopathy: Clinical profile and association with other malarial complications. Jain A, et al. Acta Trop. Epub Mar Clinical profile and complication of malaria hepatopathy. Fazil A, et al. J Infect Public Health.
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Background: The single most dreaded complication in severe malaria is cerebral malaria, but extracerebral serious complications are becoming frequent in endemic areas, which include hepatic dysfunctions with jaundice. Materials and Methods: This prospective case series study was undertaken to observe the clinical profile in 81cases of complicated malaria presenting with jaundice out of hospitalized patients diagnosed with acute severe malaria. Liver function tests were assessed and the patients were followed up to 4 weeks. Significant findings included a predominantly hemolytic jaundice mean bilirubin 7. No residual hepatic dysfunctions were detected in survivors on follow-up. Conclusion: Differentiating fulminant viral hepatitis with multi-organ failure and early treatment of associated complications are crucial to reduce mortality in malaria presenting with jaundice. Hemolytic jaundice with mild and relatively early reversibility of hepatocellular dysfunction usually points towards complicated Pf malaria.
Malarial Hepatopathy and Its Outcome in India
Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. Corpus ID: Malarial hepatopathy. Jaundice is a common clinical presentation in severe malaria, seen in approximately 2. Although hepatic dysfunction is unusual and hepatic encephalopathy is almost never seen in malaria, yet, cases of hepatic dysfunction are being increasingly reported in patients with P. View PDF. Save to Library.